Abstract: Based on distribution characters of roadway lateral abutment pressure，and pressure relief drilling hole mechanism of coal seam and plastic zone distribution character were analyzed，and ‘horn’ shape plastic zone rock burst prevention mechanism of pressure relief drilling hole in coal seam was put forward，and then reasonable pressure relief drilling hole depth of roadway side of one coal mine in Shaanxi province was determined.Based on Mohr’s failure theory，the difference that pressure relief drilling holes with different interval and different arrangement form to rock burst hazard zone relieving in specific geological situation were studied by numerical software FLAC^3D，the results of rock burst prevention and cure with pressure relief drilling hole with the optimal parameters were verified in practical.The results showed that macro-energy shake incidents were decreased obviously under drilling hole parameters，which determined according studying results，and rock burst hazard of experimental field was decreased obviously.