Abstract: To current state that multiply aquifers,rich water inflow and fragile ecological environment of Inner Mongolia and Shaanxi mine district in deep,it taking geological and mining situation of Nalinhe No.2 coal mine as background,and then number simulation,similar simulation,experiment indoor and field testing ans so on were utilized.First,water disaster prevention scheme was put forward based on overburden fracture height and characteristics and water inflow principle of mining sandstone fracture aquifer,which core idea was ‘ mining under water controlling’,second,deeply treatment technology and outfit that suit for mine water characteristics was developed to specificity of hypersalinity water and underground working environment,at the end,according drain and supply water quantity of mine,mine water comprehensive utilization for Inner Mongolia and Shaanxi mine district in deep was realized.The results applied in field successfully,no only the maximum water inrush quantity during beginning mining period was controlled effectively and ensured safety mining,but also mine water was take full advantage used,so safety,effectively and green mining was guaranteed,it referenced for similar situation.