Abstract: Aiming at addressing the challenge of preventing and controlling water and mud inrush disasters in deep-buried, long-distance tunnels, this paper, based on the Central Yunnan Water Diversion Project, proposes a “1-3-1” comprehensive technical system for forecasting, warning, and disposing adverse geological conditions in tunnels. Compared to the traditional “forecast-alert-disposal” model, this method adheres to the core objective of “engineering safety.” Through three synergistic mechanisms, namely “geology combined with forecasting,” “forecasting combined with warning,” and “forecasting combined with disposal”, it forms an integrated detection approach which prioritizes geological analysis and incorporates long-range advanced forecasting (e.g., seismic wave methods), medium-to-short-range forecasting (e.g., electromagnetic methods), and fine-scale forecasting via cross-hole CT. Building upon geological analysis, geophysical prospecting, and drilling results, the system employs a risk evaluation method combining subjective and objective factors to establish a three-tier (Class A, B, C) risk warning mechanism. Corresponding disposal measures are then implemented based on the forecasting and warning results, achieving refined detection of adverse geology and dynamic management of disaster risks. Ultimately, this method was applied to the Central Yunnan Water Diversion Project, successfully forecasting and providing warnings for 56 water and mud inrush incidents. The Xianglushan No. 2 Construction Tunnel was selected as an application case, where a Class A high-risk zone at chainage 12+226–12+240 was successfully identified. Multiple forecasting methods, including the seismic wave method, induced polarization method, advanced drilling, and cross-hole CT, were utilized to locate the high-risk zone. Subsequent advanced drilling, water inflow encountered in grouting boreholes, and excavation verified the reliability of the forecast. After the completion of advanced grouting reinforcement and pipe-roof support in accordance with the construction disposal plan, the tunnel safely traversed the high-risk zone. The research results demonstrate that this technical system can effectively enhance disaster prevention and control capabilities during the construction of tunnels under complex geological conditions, providing methodological guidance and engineering references for the safe construction of deep-buried, long-distance tunnels.