Abstract: The No. 3-1 coal seam has a strong bursting liability in Menkeqing Coal Mine, with the characteristics of large coal seam burial depth and high mining intensity, and the thick composite sandstone roof overlying the coal seam, which are prone to inducing coal burst disasters during the mining period of the working face. In response to the difficulty of achieving ideal pressure relief effects through conventional pressure relief measures for medium-high position thick and hard roof, on the basis of analyzing the factors causing disasters, the main control strata causing the disaster was determined using methods such as roof lithology analysis, key strata theory calculation, microseismic monitoring, and strata fracture energy transfer calculation, the mechanism of regional fracturing with long drilling to prevent and control coal burst was revealed, and the regional fracturing with long drilling was used to carry out disaster management engineering practice, and the corresponding effect analysis were carried out. The results show that the large burial depth of the working face provides sufficient foundation static load, the 3-1 coal seam and roof and floor system have the potential to generate coal burst, the fracture dynamic load of composite sandstone roof with strong integrity and good continuity was the main source of induced coal burst. The regional fracturing with long drilling was used for advanced prefracturing of the thick and hard composite sandstone roof, after the construction was completed, the significant crack propagation in fractured strata, and the prefracturing effect of the roof is good. During the mining of working face, the frequency, energy, and concentration of high-energy microseismic events in the fracturing area were significantly reduced, the intensity and distance of the periodic weighting of working face decreased. The engineering practice has shown the effectiveness of regional fracturing with long drilling, significantly reducing the risk of coal burst disasters and ensuring safe mining of working faces, the research results can provide reference for the prevention and control of coal burst in coal mines with similar conditions.