Abstract: To explore the coordinated prevention and control methods for rockburst and mining-induced seismicity under the condition of "multiple key strata" in thick hard roof strata commonly encountered in deep mining areas of Inner Mongolia and Shaanxi, this paper mainly carried out the following work: The influence mechanisms of thick hard roof strata at different horizons on rockburst and mining-induced seismicity were analyzed, showing that the static-dynamic load superposition caused by the hanging and fracturing of lower-positioned roof strata tends to trigger rockburst, while large-scale instability of higher-positioned roof strata releasing intense dynamic loads tends to induce mining-induced seismicity, with both linked through stress waves exacerbating disaster risks; A coordinated prevention and control approach for rockburst and mining-induced seismicity based on regional hydraulic fracturing of roof strata was proposed; A multi-dimensional discrimination technique for dominant rock strata based on "geology-energy-fracture-physical properties" was developed to locate disaster-causing horizons; A coordinated prevention and control model and method for rockburst and mining-induced seismicity were established, which weakens lower-positioned roof strata to eliminate hanging roofs for rockburst prevention and pre-fractures higher-positioned rock strata to block large structural formation for seismicity reduction, thereby achieving coordinated prevention and control of rockburst and mining-induced seismicity. This technology was experimentally explored in Hongqinghe Coal Mine, where the test working face showed a 90% reduction in daily average microseismic energy, a 57% shortening of periodic weighting intervals, and an increase in daily advance speed to 5.6 m-6.4 m. The results preliminarily verified the coordinated prevention and control effect of "continuous pressure relief in lower strata to control rockburst and layered weakening in higher strata to suppress mining-induced seismicity," providing an approach for rockburst and mining-induced seismicity management in deep mining areas of Inner Mongolia and Shaanxi.