Abstract: Targeting intense mining activities and strong ground pressure disasters induced by hard-thick roof strata in the Meng-Shan Mining Area, this study proposes technical countermeasures for ground pressure control through in-seam fracturing in hard-thick roof zones. Integrated methodologies including theoretical analysis, physical modeling, and field trials were employed to investigate key fracturing technologies. The pressure relief mechanism of hydraulic fracturing for thick-hard roof strata, centered on strata structure control, was elucidated. A comprehensive technical workflow for regional fracturing was proposed, including: determination of the target fracturing horizon, design of the fracture network and key construction parameters, drilling of underground directional long boreholes, staged fracturing within these boreholes, and monitoring and evaluation of the hydraulic fracturing effects. An integrated technological system and equipment for underground regional fracturing of thick-hard roof strata in coal mines were developed and demonstrated for pressure relief in a super-large mining height panel. The results indicated that during the trial period, a total of 174 microseismic events related to roof breakage were recorded. Among these, 141 events (81.03% of the total) had squared energy levels, with a total roof breakage energy of 7.39×10⁴ J. No major microseismic events with energy levels exceeding the fourth power occurred. The weighted average periodic weighting interval was 17.9 m, the average duration span of weightings was 10.7 m, the average leg closure was 375 mm, and the average dynamic load factor was 1.46. Practice demonstrates that regional hydraulic fracturing can promote the timely caving of thick-hard roof strata, reduce the periodic weighting interval, and effectively mitigate the intensity of ground pressure manifestations. This ensures the safe and efficient extraction of the super-large mining height panel, validating the effectiveness and applicability of the regional fracturing countermeasure for controlling powerful ground pressure in thick-hard roof strata. This research can provide a valuable reference for preventing and controlling powerful ground pressure hazards associated with thick-hard roof strata in the Mong-Shaan Mining Area.